Comparative evaluation of the effects of powdered soybean (Glycine max) and wheatgrass (Triticum aestivum) on platelet count in idiopathic thrombocytopenic purpura (ITP) in white mice (Mus musculus)

Abstract

Idiopathic Thrombocytopenic Purpura (ITP) is a hematological disorder characterized by immune-mediated destruction of platelets, leading to thrombocytopenia and an increased risk of bleeding. Conventional treatments for ITP can have significant side effects, creating a need for safer alternative therapies. Soybean <i>(Glycine max)</i> is a legume rich in proteins, isoflavones, and antioxidants, known for its anti-inflammatory and immune-modulating properties. Wheatgrass <i>(Triticum aestivum),</i> derived from young shoots of the wheat plant, contains chlorophyll, vitamins, minerals, and bioactive compounds with demonstrated hematopoietic and antioxidant effects. This study aimed to compare the effects of powdered soybean, wheatgrass, and their combination on platelet counts in white mice <i>(Mus musculus)</i> with heparin-induced ITP. Twelve mice were divided into four groups: control (distilled water), soybean, wheatgrass, and soybean- wheatgrass combination. ITP was induced via intraperitoneal injection of heparin. Treatments were administered orally once daily for seven days. Platelet counts were measured before induction and after treatment using an automated hematology analyzer. Results showed significant increases in platelet counts in all treatment groups compared to the control, with the combination group demonstrating the greatest improvement. These findings suggest that both soybean and wheatgrass, individually and synergistically, may offer therapeutic potential in managing thrombocytopenia associated with ITP.