• English
    • Filipino
    • 中文
    • 한국어
    • français
    • русский
  • English 
    • English
    • Filipino
    • 中文
    • 한국어
    • français
    • русский
  • Login
View Item 
  •   BAHÁNDÌAN Home
  • College of Arts and Sciences
  • Undergraduate Researches
  • Theses
  • Bachelor of Science in Chemistry
  • View Item
  •   BAHÁNDÌAN Home
  • College of Arts and Sciences
  • Undergraduate Researches
  • Theses
  • Bachelor of Science in Chemistry
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Potential alpha-amylase and alpha-glucosidase inhibitory activity of bioactive fractions from alugbati (Basella alba) leaves

Thumbnail
View/Open
Thesis abstract (51.03Kb)
Downloads: 3
Page views
21
Date
2022-06
Author
Bendoy, Ma. Mitzi P.
Thesis Adviser
Villalobos, Mizpah C.
Defense Panel Chair
Borlongan, Ilda G.
Defense Panel Member
Japitana, Ma. Mercy ORCID
Panadero, Aira Rose P.
Share 
 
Metadata
Show full item record

Abstract
This study evaluated the potential in vitro inhibitory activity of Basella alba leaves against enzyme markers of diabetes mellitus, α-amylase, and α-glucosidase. The dried plant sample was ground into fine powder, defatted, and soaked in methanol to obtain the crude extract. The crude methanolic extract of Basella alba was then fractionated sequentially in acetone-methanol mixtures with increasing solvent polarity ratios. Fractions obtained were evaluated for their α-amylase and α-glucosidase inhibitory potential. The standard drug, acarbose inhibited 37.44 ± 7.65%, 83.99 ± 0.86%, and 86.52 ± 0.40% of α-amylase activity at 10, 30, and 50 ppm. The highest inhibition was observed in the acetone-methanol (4:1) fraction which inhibited 57.80 ± 0.71%, 56.39 ± 0.49%, and 46.94 ± 0.26% of α-amylase activity, followed by the acetone fraction with inhibitory activity of 22.24 ± 0.41%, 38.05 ± 0.68%, and 46.62 ± 0.32% at increasing concentrations of 50, 200, and 350 ppm, respectively. The acetone-methanol (1:4) mixture exhibited the lowest activity at 8.00 ± 0.35% for 50 ppm, and 0.61 ± 0.27% for 200 ppm. However, no inhibitory activity was demonstrated in any of the fractions of Basella alba against α-glucosidase. Total flavonoid content analysis revealed that all fractions have the same flavonoid content. Basella alba may serve an essential role in managing the risk of diabetes mellitus and is recommended for consumption on a regular basis.
Description
Abstract only
URI
https://hdl.handle.net/20.500.12852/2426
Suggested Citation
Bendoy, M. M. P. (2022). Potential alpha-amylase and alpha-glucosidase inhibitory activity of bioactive fractions from alugbati (Basella alba) leaves (Unpublished thesis). Central Philippine University, Jaro, Iloilo City.
Type
Thesis
Subject(s)
Diabetes OCLC - FAST (Faceted Application of Subject Terminology); Diabetes--Prevention OCLC - FAST (Faceted Application of Subject Terminology); Amylases OCLC - FAST (Faceted Application of Subject Terminology); Amylases--Inhibitors OCLC - FAST (Faceted Application of Subject Terminology); Glucosidases OCLC - FAST (Faceted Application of Subject Terminology); Glucosidase inhibitors OCLC - FAST (Faceted Application of Subject Terminology); Plant bioactive compounds OCLC - FAST (Faceted Application of Subject Terminology); Bioactive compounds OCLC - FAST (Faceted Application of Subject Terminology)
Keywords
Alugbati; Basella alba AGROVOC; Diabetes Mellitus MeSH
Department
College of Arts and Sciences
Degree
Bachelor of Science in Chemistry
Shelf Location
Filipiniana Theses 540.72 B433
Physical Description
vii, 36 leaves
Collections
  • Bachelor of Science in Chemistry [11]

Contact Us | Send Feedback | https://creativecommons.org/licenses/by/4.0/ Logo by HLL
Central Philippine University © 2023
Managed by 
Henry Luce III LibraryHenry Luce III Library
 

 

Links
BAHÁNDÌAN Repository GuideDisclaimerFAQsSubmit your workNews and Updates

Browse

All of BAHÁNDÌANCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Statistics

View Usage Statistics
CPU Henry Luce III Library

Contact Us | Send Feedback | https://creativecommons.org/licenses/by/4.0/ Logo by HLL
Central Philippine University © 2023
Managed by 
Henry Luce III LibraryHenry Luce III Library
 

 

EXTERNAL LINKS DISCLAIMER

This link is being provided as a convenience and for informational purposes only. Central Philippine University bears no responsibility for the accuracy, legality or content of the external site or for that of subsequent links. Contact the external site for answers to questions regarding its content.

If you come across any external links that don't work, we would be grateful if you could report them to the repository administrators.

Click DOWNLOAD to open/view the file. Chat Bertha to inform us in case the link we provided don't work.

Download