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Bioactive components from cucamelon (Melothria scabra) with potential α-amylase and α-glucosidase inhibitory activity

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Date
2022-07
Author
Heria, Melrose B.
Thesis Adviser
Villalobos, Mizpah C.
Defense Panel Chair
Borlongan, Ilda G.
Defense Panel Member
Japitana, Ma. Mercy ORCID
Panadero, Aira Rose P.
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Abstract
Cucamelons (Melothria scabra) are found growing in the wild in the Philippines. The lack of available literature regarding the plant species prompted to conduct of this study. This study aimed to extract and fractionate bioactive components from cucamelon with potential α-amylase and α-glucosidase inhibitory activity. Cucamelon fruit samples were obtained from Brgy. Pagsanga-an Pavia, Iloilo, extracted with methanol, fractionated using silica column chromatography, and assayed for α-amylase and α-glucosidase inhibitory activity. Results show that most but not all of the fractions have α-amylase inhibitory activity. Only four fractions showed α-amylase activity, namely, acetone (8.97 ± 1.54), acetone: methanol, 4:1 (15.54 ± 2.12), acetone: methanol, 3:2 (11.30 ± 2.51), and acetone: methanol, 1:4 (17.94 ± 2.19). Only one fraction had α-glucosidase inhibitory activity, which is acetone: methanol, 3:2 (3.59 ± 1.10). Cucamelon has a low inhibitory activity for α-amylase and α-glucosidase, enzyme markers of diabetes, which can be compensated by increasing the daily intake. It is recommended that unripe cucamelon fruits can be eaten regularly as salads, or pickled to help prevent the risk of developing diabetes.
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Abstract only
URI
https://hdl.handle.net/20.500.12852/2425
Suggested Citation
Heria, M. B. (2022). Bioactive components from cucamelon (Melothria scabra) with potential α-amylase and α-glucosidase inhibitory activity (Unpublished thesis). Central Philippine University, Jaro, Iloilo City.
Type
Thesis
Subject(s)
Bioactive compounds OCLC - FAST (Faceted Application of Subject Terminology); Amylases OCLC - FAST (Faceted Application of Subject Terminology); Amylases--Inhibitors OCLC - FAST (Faceted Application of Subject Terminology); Glucosidases OCLC - FAST (Faceted Application of Subject Terminology); Glucosidase inhibitors OCLC - FAST (Faceted Application of Subject Terminology)
Keywords
Cucamelon; Melothria scabra
Department
College of Arts and Sciences
Degree
Bachelor of Science in Chemistry
Shelf Location
Filipiniana Theses 540.72 H423
Physical Description
vii, 40 leaves
Collections
  • Bachelor of Science in Chemistry [11]

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